108 4TH AVENUE S, SAFETY HARBOR, FL, 34695

We are proud to present 108 4th Avenue South, a well-located professional office building just steps from Main Street in the heart of downtown Safety Harbor. Positioned in one of Tampa Bay’s most desirable and walkable submarkets, this property offers a rare opportunity for an owner-user or investor to acquire a highly functional office asset in a nationally recognized small-town setting. Constructed in 1957, the 3,812 SF building sits on approximately 0.16 acres and is located in Flood Zone X. The property is currently configured as a medical office, featuring a welcoming front waiting area and reception desk, ten private offices, a dedicated conference room, three restrooms, and a kitchen. The efficient layout provides flexibility for a variety of professional uses, including medical, legal, financial, counseling, or general office operations. For additional information, please review the floor plan. The building benefits from two primary entrances on the east and west sides of the property, allowing for convenient access, potential tenant separation, or functional flow for staff and clients. Excellent office sizes and a practical floor plan contribute to the property’s overall usability and long-term adaptability. Just off Main Street, the location offers exceptional visibility and immediate proximity to Safety Harbor’s restaurants, boutiques, breweries, waterfront parks, and community amenities. The property is also steps away from the lively Third Friday Street Festival, a monthly celebration of music, art, food, and local culture that draws consistent foot traffic and reinforces the area’s vibrant atmosphere. Safety Harbor has recently been recognized by USA Today as the #10 Best Main Street in the United States and the #5 Best Small Town in the South, underscoring the strength of the local market and the long-term appeal of downtown ownership. Whether utilized as a professional office, medical practice, or boutique business headquarters, 108 4th Avenue South offers a compelling combination of location, functionality, and community presence in one of Florida’s most charming coastal towns.

Income and lease details aren’t published in the MLS for this listing. Ask for the offering memorandum and rent roll to run cap rate, NOI and cash-on-cash.

The most comparable commercial properties that changed hands nearby. No two are identical — ask us for a full comparative analysis.

$70,000

701 ENTERPRISE ROAD E UNIT 100

3,460 sqft · $20/sqft · Sold Nov 14, 2025

$955,000

2641 & 2645 SUNSET POINT ROAD

4,458 sqft · $214/sqft · Sold Jul 10, 2025

$475,000

911 SAINT PETERSBURG DRIVE W

2,212 sqft · $215/sqft · Sold Mar 24, 2025

Pick a day that works — this goes straight to David's phone and CRM.

Keep looking

Similar properties nearby

$1,350,000

135 4TH AVENUE N, SAFETY HARBOR

Retail · 2,120 sqft

$1,100,000

1060 HARBOR LAKE DRIVE, SAFETY HARBOR

Warehouse · 4,720 sqft